About Aramchol^™

Aramchol^™ (arachidyl amido cholanoic acid) is a novel fatty acid bile acid conjugate. Aramchol^™ is a first in class, orally active, liver targeted SCD – 1 modulator with a dual mode of action on liver fibrosis, down regulation of steatosis and a direct effect on Hepatic Stellate Cells (HSC’s), the human collagen producing cells. Aramchol^™ has shown down regulation of liver steatosis and fibrosis in multiple animal models (see also publication section) demonstrating its effect on the three key pathologies of NASH: steatosis, inflammation and fibrosis. The effect of Aramchol^™ on NASH pathologies in animals was translated into humans in a phase IIa clinical study and is currently being examined in the Phase IIb ARREST study (see also Clinical Development section). To date, over 400 patients have been exposed to Aramchol^™ across 7 clinical trials. No safety and tolerability signals have been identified thus far. Aramchol^™ has been granted Fast Track designation status by the FDA for the treatment of NASH.

First-in-class, orally active, liver targeted SCD‑1 modulator

Potent mechanism with multiple intervention points along the pathogenic pathway

Effects in animal models into human ctranslated linical data

High safety margin and B/R ratio

~400 subjects exposed across 7 clinical trials

Fast Track Designation for development of Aramchol^™ for NASH granted by FDA