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Mechanism of Action

Stearoyl-CoA desat­urase (SCD1) cat­alyzes the rate-lim­iting step in the biosyn­thesis of monoun­sat­u­rated fatty acids and therefore is con­sidered a potent mech­anism in liver steatosis and fibrosis. Mice with a tar­geted dis­ruption of the SCD1 isoform have reduced body adi­posity, increased energy expen­diture, and up-reg­u­lated expression of several genes encoding enzymes and tran­scription factors enhancing fatty acid oxi­dation and reducing fibro­ge­nesis in liver including AMPK and SIRT.

Aramchol Reduces Steatosis, Oxidative Stress and Liver Injury

Graph Aramchol™ Reduces Steatosis, Oxidative Stress and Liver Injury

Iruarrizaga‐Lejarreta, Marta, et al. “Role of Aramchol in steato­hep­atitis and fibrosis in mice.” Hepa­tology Com­mu­ni­ca­tions 1.9 (2017): 911–927.

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